Professor David W Holt
BSc, PhD, DSc (Med), CSci, EurClin Chem, EFESC, FRCPath
Professor Holt is a clinical biochemist with over 40 years’ experience in the measurement of drugs as a guide to therapy. Following original work, on the clinical pharmacokinetics of antiarrhythmic agents, in particular amiodarone, performed at the Poisons Unit, Guy's Hospital in London, he became involved in clinical studies on ciclosporin. Since 1982 this interest has resulted in a number of studies related to the measurement of a wide range of established and investigational immunosuppressive agents in clinical and pre-clinical studies
Currently, he is Emeritus Professor of Bioanalytics at St George’s - University of London, and a Director of Analytical Services International Ltd. Since 1984 he has co-ordinated the International Proficiency Testing Schemes for immunosuppressive drugs.
Professor Holt has advised on several consensus panels on immunosuppressive drug monitoring His current research interests include the development of mass-spectrometric assays for the measurement of endogenous markers of organ damage and dysfunction, pharmacogenetics, the development of methods for the detection of drugs used in drug-facilitated crime and clinical problems related to counterfeited drugs.
Professor Holt is a frequent speaker on a broad range of issues relating to bioanalytics and clinical toxicology, and is the author of over 300 publications in peer reviewed journals and invited contributions to books. He is an active member of several national and international scientific societies involved in transplantation and cardiology.
In 2005 Professor Holt was presented with the Charles E Pippenger award for Outstanding Contributions to Therapeutic Drug Monitoring.
He is a Past President of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology.