Services
Therapeutic Drug Monitoring
We work with hospitals, mental health services and other healthcare organisations across the UK and Ireland, providing reliable analysis for drugs that require close monitoring due to narrow therapeutic ranges or complex pharmacokinetics.
Analytical Services International (ASI) provides therapeutic drug monitoring services to support clinicians and healthcare providers in delivering safe and effective patient care. Our TDM service offers accurate drug concentration measurement, expert interpretation and clinically relevant turnaround times that help guide treatment decisions.
Select an area below to explore our expertise in more detail.
How Therapeutic Drug Monitoring Supports Patient Care
TDM helps ensure that a patient receives an appropriate dose of medication. Measuring drug concentrations can support clinical decision making in situations such as:
Lack of therapeutic response
Suspected toxicity
Changes in a patient’s clinical condition
Adjustments to dose or treatment regimen
Potential drug interactions
Concerns regarding adherence
ASI provides therapeutic drug monitoring (TDM) services to support clinicians and healthcare providers in delivering safe and effective patient care. Our TDM service offers accurate drug concentration measurement, expert interpretation and clinically relevant turnaround times that help guide treatment decisions.
Drugs We Monitor
ASI provides validated assays for a range of clinically important medications, including:
Antipsychotic medicines, such as clozapine and olanzapine
All other first and second-generation antipsychotics
Immunosuppressants, including everolimus, sirolimus and mycophenolic acid
Anti-arrhythmic drugs - flecainide
Our methods measure the active pharmaceutical ingredient and, where clinically useful, relevant metabolites that may influence treatment response or reflect patterns of adherence.
Speak to Our Experts
Clozapine Monitoring
ASI offers a dedicated clozapine monitoring service supported by an encrypted online portal. Registered clinicians can:
Access patient results securely
Support adherence assessments
Monitor clinical stability over time
Review historical results by patient
This service provides convenient access to results in a format that supports ongoing clinical review.
Our TDM Process
Sample Collection
Samples are usually taken at the end of the dosage interval, often referred to as the trough level. Appropriate sample type and timing help ensure the result is clinically meaningful.
Information Requirements
To support accurate interpretation, relevant information should accompany each sample, such as dose, time of collection, concomitant medication, reason for request and any clinical concerns.
Laboratory Analysis
All assays are performed using validated methods with appropriate sensitivity and specificity. Analysis is carried out by experienced scientists and supported by internal quality controls and participation in external quality schemes.
Reporting and Interpretation
Results are reviewed before release and provided in mass units with reference ranges where appropriate. Interpretation considers individual patient factors, published therapeutic guidance and any additional information supplied by the requester.
Why Therapeutic Drug Monitoring Matters
TDM can play an important role in:
Detecting toxicity, overdose or drug interactions
Supporting dose adjustments
Improving patient outcomes through personalised care
Identifying treatment failure or non-adherence
Maximising therapeutic effectiveness
Why Choose ASI for your Therapeutic Drug Monitoring?
Extensive experience in clinical and forensic bioanalysis
Validated, high quality assays for key therapeutic agents
Clinically relevant turnaround times
Dedicated encrypted microsite for clozapine results
Clear reporting and expert interpretation
Accredited laboratory environment with robust quality systems
Speak to Our Forensic Team
If you would like to discuss specific drugs, assay availability or service requirements, our team is available to help.
What people say about us
“Our pharmacokinetic research collaboration with ASI was seamless from consultation to reporting. The team demonstrated clear expertise, arranged efficient sample logistics and delivered results within our research timeframe.”
“We have worked with ASI for over 20 years. The team is responsive, knowledgeable and reliable, delivering high-quality services at good value.”
“ASI developed and validated our pharmacokinetic assay to a high scientific standard. The work was delivered on time and with clear scientific rigour.”
“We would confidently recommend ASI to others and look forward to future collaborations. Their consistent communication, responsiveness and commitment to quality have been invaluable.”
“ASI supported our large-scale research study with professionalism and flexibility. Their responsiveness during an extended data collection period was particularly valued. We would be pleased to work with them again.”
“Across two clinical trials, ASI delivered accurate and efficient bioanalytical services. Their commitment to quality reporting was evident throughout.”
“It has been a genuine pleasure working with ASI. We would not hesitate to recommend them and hope to collaborate again in future.”
FAQs: All You Need to Know
Which medicines do you monitor through therapeutic drug monitoring?
We provide TDM for selected antipsychotics, psychotropic medicines, immunosuppressants and cardiac drugs. Assay availability can be confirmed on request.
How should samples be timed for therapeutic drug monitoring?
Samples are usually collected at the end of a dosing interval. Trough sampling allows for results that better reflect steady state concentrations.
Can you provide interpretation with TDM results?
Yes. Our reports include concentration data with appropriate reference information. Interpretation takes account of clinical context and information supplied with the request.
How quickly are TDM results available?
Turnaround times are designed to support clinical decision making and can be confirmed at the time of request.
Do you offer a secure system for clinicians to access clozapine results?
Yes. Registered users can access clozapine results through our encrypted online portal, which also provides trend reporting.
Get in Touch
We welcome enquiries from new and existing clients. Whether you require toxicology support, clinical bioanalysis, therapeutic drug monitoring or expert interpretation, our team is here to help.
General Enquiries & Helpline
info@bioanalytics.co.uk
+44 (0)20 8725 2405